Journal
SCHIZOPHRENIA RESEARCH
Volume 118, Issue 1-3, Pages 113-117Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2010.01.014
Keywords
Schizophrenia; Japanese population; Epistasis; KREMEN1; DKK1; wnt pathway
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labor and Welfare of Japan
- Core Research for Evolutional Science and Technology
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The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.
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