Journal
SCHIZOPHRENIA RESEARCH
Volume 119, Issue 1-3, Pages 75-78Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2009.12.021
Keywords
Cortisol; Hippocampus; Psychosis; HPA axis; Schizophrenia; Glucocorticoids
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Funding
- King's College Development Trust (UK)
- NARSAD
- KCL
- South London and Maudsley NHS Foundation Trust & Institute of Psychiatry NIHR Biomedical Research Centre for Mental Health
- BIAL Foundation
- British Academy
- APIRE
- UK Medical Research Council
- Medical Research Council [G9817803B, G108/603] Funding Source: researchfish
- National Institute for Health Research [CL-2008-17-005] Funding Source: researchfish
- MRC [G108/603] Funding Source: UKRI
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This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion. (C) 2009 Elsevier B.V. All rights reserved.
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