Journal
SCHIZOPHRENIA RESEARCH
Volume 107, Issue 2-3, Pages 173-178Publisher
ELSEVIER
DOI: 10.1016/j.schres.2008.09.018
Keywords
First-episode; Psychosis; Course of illness; Recovery Risk factors
Categories
Funding
- Danish Ministry of Health [96-0770-71]
- Danish Ministry of Social Affairs
- University of Copenhagen
- Copenhagen Hospital Cooperation
- Danish Medical Research Council [9601612, 9900734]
- Slagtermester Worners Foundation
- Stanley Wada Research Foundation
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There is an ongoing debate as to whether psychosis is a progressively deteriorating illness or one of progressive amelioration. This paper aims at investigating the rate of recovery and institutionalization and predicting a continuous illness course in a descriptive prospective study of a sub-sample of the OPUS trial of 265 first-episode psychotic patients after five years. Recovery, defined as no psychotic or negative symptoms, living independently, GAF (f)>59, working or studying, was reached for 18% after five years, whereas 13% were institutionalized either at hospital or supported housing after five years. Male gender (OR 1.9, 95% CI 1.06 to 3.23), premorbid social functioning (OR 1.2, 95% CI 1.01 to 1.33), psychotic symptoms (OR 1.3, 95% CI 1.07 to 1.66), and negative symptoms (OR 1.3, 95% CI 1.01 to 1.67) were found to predict a continuous illness course at five-year follow-up. Rates of recovery and institutionalization contradict the assumption that the illness deteriorates progressively, since no changes in the rates are seen from two to five years. (C) 2008 Elsevier B.V. All rights reserved.
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