Journal
SCHIZOPHRENIA RESEARCH
Volume 109, Issue 1-3, Pages 90-93Publisher
ELSEVIER
DOI: 10.1016/j.schres.2009.02.005
Keywords
Matrix metalloproteinase-9; -1562 T/C polymorphism; Schizophrenia
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Funding
- Polish Ministry of Science and Higher Education [N40208631/2644]
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Matrix metalloproteinase-9 (MMP-9) plays a role in many pathological conditions (e.g. cancer and heart disease). Recently, MMP-9 has been implicated in the activity of the prefrontal cortex and we therefore hypothesized that the MMP-9 gene may be associated with schizophrenia. We genotyped the functional - 1562C/T polymorphism in a group of 442 schizophrenia patients and in 558 healthy control subjects. A significant preponderance of C/C genotype and C allele was found in the schizophrenia subjects compared to healthy controls. The results may provide the first evidence for involvement of the MMP-9 gene in the pathogenesis of schizophrenia and could also contribute to explaining a genetic connection between schizophrenia and some somatic illnesses. (C) 2009 Elsevier B.V. All rights reserved.
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