Journal
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
Volume 37, Issue 6, Pages 414-418Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03009740802256327
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Funding
- Association Francaise des Polyarthritiques
- Association Rhumatisme et Travail
- European Union for AutoCure
- Ministere de l'Enseignement Superieur
- de la Recherche Scientifique de la Technologie (Tunisia)
- International Centre for Genetic Engineering and Biotechnology (ICGEB) Trieste (Italy)
- Foundation for Science and Technology, Portugal [SFRH/BD/23304/2005]
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Objective: A strong genetic association of rheumatoid arthritis (RA) with the interferon regulatory factor 5 (IRF5) gene has been described previously in a Swedish population, although this result was not confirmed in a French population. We undertook an association study between IRF5 and the RA phenotype, as well as a study with serological markers of RA, in a Tunisian population. Methods: A single-nucleotide polymorphism (SNP; rs2004640) was genotyped using a Taqman 5' allelic discrimination assay on an ABI 7500 real-time polymerase chain reaction (PCR) instrument in 140 RA patients and 185 controls. Rheumatoid factor (RF) and anti-citrullinated protein/peptide antibodies (ACPA) were determined by enzyme-linked immunosorbent assay (ELISA). Association was assessed based on the chi(2) test and odds ratios (ORs) with 95% confidence intervals (CIs). Results: The frequency of the TT genotype of the IRF5 SNP rs2004640 differed significantly between patients and controls (p=0.01). This difference was greater when a subgroup of patients with another 'autoimmune' disorder was considered (p=0.007). A weak but significant association was also found in a subgroup of patients who were positive for ACPA (p=0.04) or erosion (p=0.01). Conclusions: Our results indicate that the TT genotype of the IRF5 (rs2004640) dimorphism is associated with RA in a Tunisian population.
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