Journal
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
Volume 24, Issue 4, Pages E220-E229Publisher
WILEY
DOI: 10.1111/sms.12149
Keywords
relaxin; motor organs; skeletal muscle; tendon; ligament
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Funding
- PPP grant, University of Malaya, Kuala Lumpur, Malaysia [PV104/2012A]
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Relaxin is a hormone structurally related to insulin and insulin-like growth factor, which exerts its regulatory effect on the musculoskeletal and other systems through binding to its receptor in various tissues, mediated by different signaling pathways. Relaxin alters the properties of cartilage and tendon by activating collagenase. This hormone is also involved in bone remodeling and healing of injured ligaments and skeletal muscle. In this review, we have summarized the literature on the effect of relaxin in musculoskeletal system to provide a broad perspective for future studies in this field.
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