Journal
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
Volume 42, Issue 5, Pages 379-384Publisher
INFORMA HEALTHCARE
DOI: 10.3109/00365540903501608
Keywords
-
Categories
Ask authors/readers for more resources
The risk of seroconversion for multiple human papillomavirus (HPV) types over time was studied in a cohort of 532 women with cervical HPV infection, prospectively followed-up for > 10 y. Of the women who were HPV-antibody positive for at least 1 of the HPV types (6, 11 (low risk, lr), 16, 18, 31, 33, and 45 (high risk, hr)) at baseline, 73-98% seroconverted for 1 or more HPV types over time. Baseline lrHPV-seropositive women had 2.3-fold risk (95% confidence interval (CI) 1.1-4.7) for hrHPV seroconversion, but the opposite was not the case. Cross-protection by the natural HPV16 or HPV18 infection against other types of the HPV species A9 or A7 was not seen. These data suggest that protection against other HPV genotypes (as indicated by the lack of seroconversion) may not be provided by humoral HPV antibodies derived from a natural infection. Instead, these unvaccinated, HPV-antibody-positive women continue to be susceptible to infections by the other HPV genotypes over time.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available