Journal
RSC ADVANCES
Volume 5, Issue 46, Pages 36837-36844Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra04669f
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Funding
- 973 Program [2013CB834702]
- Natural Science Foundation of China [51373063, 21204027, 21221063]
- Research Fund for the Doctoral Program of Higher Education of China [20120061120016]
- Graduate Innovation Fund of Jilin University [2014013]
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Near-infrared emissive organic dots with a high fluorescence quantum efficiency (AEE dots) are prepared by using an amphiphilic polymer poly(styrene-co-maleic anhydride) (PSMA) as the co-encapsulation matrix and a novel small molecule fluorogen (DPPBPA) with high near-infrared emission as the core. The PSMA dots show small particle size of about 20 nm, a large Stokes shift of 304 nm and really high fluorescence quantum efficiency of 20%. The streptavidin-dots are obtained by conjugating streptavidin to carboxyl groups on the surface of PSMA dots. These streptavidin-dots can effectively and specifically label the target cell without any nonspecific binding, such as MCF-7 cells. Together with the negligible cytotoxicity, the near-infrared emissive AEE dots are promising red fluorescent probes for future bioimaging applications.
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