Journal
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Volume 73, Issue 2, Pages 122-127Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-3083.2010.02480.x
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Funding
- The Kornerup Fund
- The Aage and Johanne Louis-Hansen Fund
- The Aase and Ejnar Danielsen Fund
- Den Midtjyske Bladfond
- The Christian and Ingeborg Andersen Fund
- The Beckett Fund
- The Walter and O. Kristiane Christensen Fund
- The Ulla and Mogens Folmer Andersen Fund
- The Else and Aage Gronbeck-Olsen Fund
- The Sven and Ina Hansen Fund
- The Harboe Fund
- The Leo Foundation
- The Hede-Nielsen Family Fund
- The Henrik Henriksen Fund
- The Sophus and Astrid Jacobsen Fund
- The Arvid Nilsson Fund
- The Kathrine and Vigo Skovgaard Fund
- The Einar Willumsen Fund
- The Else and Mogens Wedell-Wedellsborg Fund
- The Danish Research Council
- The Danish Cancer Society
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Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are key factors of the lectin pathway of complement activation. Polymorphisms of the MBL2 and MASP-2 genes affect serum levels of MBL and MASP-2. In patients with colorectal cancer (CRC), the MBL and MASP-2 serum levels are increased and high MASP-2 levels are associated with recurrence and poor survival, whereas low MBL levels predict post-operative pneumonia. It is not known whether these associations are genetically based. In this study, the MBL and MASP-2 genotypes are investigated in 593 patients with CRC and 348 healthy controls. The potential association between genetic profile and infections, recurrence and survival is evaluated. Four single-nucleotide polymorphisms (SNPs) of MBL2 were analysed using TaqMan assays, with characterization of MBL2 wildtype A, variants B, C and D and alleles H/L, Y/X and P/Q. The SNP D120G for MASP-2 was determined. Serum levels of MBL and MASP-2 were measured. The MBL2 and MASP-2 genotype distribution was similar among patients with CRC and healthy controls and MBL2 genotype significantly associated with MBL concentration in serum (P < 0.0001). No significant association between MBL2/MASP-2 genotype and post-operative infectious complications (P = 0.33 and 0.22), recurrent cancer or survival (P = 0.74 and P = 0.61 respectively) was found. Thus, the increased serum levels of MBL and MASP-2 found in patients with CRC are not explained for by genetic profiles. In contrast to what has been demonstrated for serum levels of MBL and MASP-2, the genotypes do not predict disease course of the CRC patients.
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