Journal
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Volume 71, Issue 4, Pages 227-231Publisher
WILEY
DOI: 10.1111/j.1365-3083.2010.02383.x
Keywords
-
Categories
Funding
- Chinese National Science Foundation [30671149, 30971584]
- China New Century Excellent Talents of Ministry of Education [NCET-07-0859]
Ask authors/readers for more resources
MicroRNAs (MiRNAs) belong to a class of small non-coding regulatory RNAs that act through repression of protein expression at post-transcriptional level and emerge to play important roles in many physiological and pathophysiological processes. MiR-146a is a miRNA supposed to regulate innate immune, inflammatory response and antiviral pathway negatively. In this review, we focus on the recent progress in functional role of miR-146a in innate immune, inflammatory response, virus infection and human diseases. Together, these findings indicate that manipulation of miR-146a expression may represent a potential new therapy for several human diseases. Potential use of miR-146a as a biomarker for disease diagnosis, prevention and treatment is also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available