Journal
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Volume 47, Issue 2, Pages 184-190Publisher
INFORMA HEALTHCARE
DOI: 10.3109/00365521.2011.647062
Keywords
adenoma; colonoscopy; population-based; prospective
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Funding
- Swedish Research Council
- Ersta Hospital, Stockholm, Sweden
- Foundation Tornspiran, Stockholm, Sweden
- AstraZeneca R D, Sweden
- Ferring L kemedel AB
- Stockholm County Council
- Karolinska Institutet
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Objective. There are few prospective studies of the prevalence of colonic neoplasia in the normal population. In order to properly evaluate screening-protocols for colorectal cancer in risk groups (e. g., older subjects or those with a family history), it is essential to know the prevalence of adenomas and cancer in the normal population. Methods. A prospective population-based colonoscopy study on 745 individuals born in Sweden aged 19-70 years was conducted (mean age 51.1 years). All polyps seen were retrieved and examined. Results. Out of the 745 individuals 27% had polyps, regardless of kind. Adenomas were found in 10% of the individuals and finding of adenomas was positively correlated to higher age. Men had adenomas in 15% and women in 6% of the cases. Women had a right-sided dominance of adenomas. Hyperplastic polyps were seen in 21% of the individuals. The presence of hyperplastic polyps was significantly positively correlated to the presence of adenomas. Advanced adenomas were seen in 2.8% of the study participants, but no cancers were detected. Conclusion. One in 10 healthy subjects had an adenoma but advanced adenomas were uncommon. Men and women have a different adenoma prevalence and localization. The results provide baseline European data for evaluating colonoscopy screening-protocols for colorectal cancer risk groups, and the findings may have implications for colon cancer screening in the normal, otherwise-healthy population.
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