Journal
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Volume 46, Issue 9, Pages 1057-1064Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/00365521.2011.584895
Keywords
Bifidobacterium lactis HN019; gastrointestinal; probiotic; whole gut transit time
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Funding
- Fonterra Research Centre (Palmerston North, New Zealand)
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Objective. To assess the impact of Bifidobacterium lactis HN019 supplementation on whole gut transit time (WGTT) and frequency of functional gastrointestinal (GI) symptoms in adults. Material and methods. We randomized 100 subjects (mean age: 44 years; 64% female) with functional GI symptoms to consume a proprietary probiotic strain, B. lactis HN019 (Fonterra Research Centre, Palmerston North, New Zealand), at daily doses of 17.2 billion colony forming units (CFU) (high dose; n = 33), 1.8 billion CFU (low dose; n = 33), or placebo (n = 34) for 14 days. The primary endpoint of WGTT was assessed by X-ray on days 0 and 14 and was preceded by consumption of radiopaque markers once a day for 6 days. The secondary endpoint of functional GI symptom frequency was recorded with a subject-reported numeric (1-100) scale before and after supplementation. Results. Decreases in mean WGTT over the 14-day study period were statistically significant in the high dose group (49 perpendicular to 30 to 21 perpendicular to 32 h, p < 0.001) and the low dose group (60 perpendicular to 33 to 41 perpendicular to 39 h, p = 0.01), but not in the placebo group (43 +/- 31 to 44 +/- 33 h). Time to excretion of all ingested markers was significantly shorter in the treatment groups versus placebo. Of the nine functional GI symptoms investigated, eight significantly decreased in frequency in the high dose group and seven decreased with low dose, while two decreased in the placebo group. No adverse events were reported in any group. Conclusions. Daily B. lactis HN019 supplementation is well tolerated, decreases WGTT in a dose-dependent manner, and reduces the frequency of functional GI symptoms in adults.
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