Journal
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Volume 46, Issue 4, Pages 428-435Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/00365521.2010.537680
Keywords
Exendin 9-39; gastric emptying; GLP-1; glucagon; insulin
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Funding
- Novo-Nordisk Foundation
- Prof. Nanna Svartz Fund
- Bengt Ihre Foundation
- Karolinska Institute Faculty Foundation
- Danish Medical Research Council
- Swedish Research Council
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Objective. To study the role of endogenous glucagon-like peptide-1 (GLP-1) on gastric emptying rates of a solid meal as well as postprandial hormone secretion and glucose disposal. Material and methods. In nine healthy subjects, gastric emptying of a 310-kcal radio-labelled solid meal and plasma concentrations of insulin, glucagon and glucose were measured during infusion of saline or the GLP-1 receptor antagonist exendin(9-39)amide (Ex(9-39)) at 300 pmol center dot center dot kg
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