Journal
RSC ADVANCES
Volume 5, Issue 32, Pages 25295-25303Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra01307k
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Funding
- National Natural Science Foundation of China [21174142, 51233004, 51390484, 51321062]
- Ministry of Science and Technology of China [2011DFR51090]
- Jilin province science and technology development program [20130521011JH]
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Prevention of adhesion after tendon repair surgery is of considerable importance during tendon healing; however, current clinical outcomes are still not fully satisfactory. In this study, thermosensitive 5-fluorouracil (5-Fu) loaded PLGA-PEG-PLGA hydrogels were used as injectable physical barriers for the prevention of tissue adhesion during tendon healing and inhibition of fibroblast proliferation. The 5-Fuloaded hydrogels showed a sol-gel-precipitation phase transition with increasing temperature, and the hydrogels displayed the maximum storage moduli at around physiological temperature. The sustained release of 5-Fu from the hydrogels lasted over 7 days. The PLGA-PEG-PLGA hydrogels degraded within 4 weeks after subcutaneous injection into rats, and showed acceptable biocompatibility in vivo. The anti-adhesion efficacy of the hydrogels, with or without 5-Fu, during the Achilles tendon healing of rats was evaluated by macroscopic and histological analysis. It was found that the group treated with 5-Fuloaded hydrogels showed a significant inhibition of adhesion formation when compared to the untreated group or the group treated with the hydrogels only. Therefore, the 5-Fu-loaded injectable hydrogels hold potential as efficient physical barriers for the prevention of adhesion formation during Achilles tendon healing.
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