A Study of Ibuprofen Solubility in Supercritical Carbon Dioxide by Fourier-Transform Infrared Spectroscopy

In the work, a method of study of solubility of pharmaceutical substances in high-pressure gases and supercritical media with Fourier-transform IR spectroscopy has been developed. An investigation of the process of ibuprofen dissolution in supercritical carbon dioxide (SC CO2) in a real-time scale has been performed. On the basis of analysis of the time dependences of the integral intensities of the selected IR-absorption bands of ibuprofen on the value of the initial weighed portion the value of solubility (molar fraction) of ibuprofen in SC CO2 at a temperature of 35A degrees C and pressure of 15.0 MPa was obtained, being equal to (8.9 +/- 1.6) x 10(-3).