Journal
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
Volume 89, Issue 2, Pages 275-281Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0036024415020259
Keywords
enantioselective adsorption; chromatography; chiral stationary phase; enantiomers; ibuprofen
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Funding
- Russian Federation [MK-675.2013.3]
- Russian Foundation for Basic Research [13-03-00464-a, 13-03-92692]
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The adsorption of ibuprofen enantiomers on a chiral stationary phase Nautilus-E with a grafted antibiotic eremomycin from aqueous ethanol acetate buffer solutions was studied by chromatography. The ethanol concentration in the mobile phase was varied from 40 to 60 vol %. The adsorption isotherms of both enantiomers had a complex shape characterized by non-Langmuir type curvature and the presence of an inflection point. This is explained by two factors: the energy heterogeneity of the surface of the stationary phase and the dissociation of ibuprofen in the liquid phase. The effect of the system peak on the shape of the chromatograms of the target component was investigated. The temperature effect on the adsorption equilibrium was discussed.
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