Journal
RSC ADVANCES
Volume 5, Issue 37, Pages 28892-28895Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra16896h
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Funding
- National Science Foundation of China [NSF 21402066]
- Natural Science Foundation of Jiangsu Province [BK20140139]
- Fundamental Research Funds for the Central Universities [JUSRP11419]
- SAFEA for the 111 project [B13025]
- MOE
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A copper-catalyzed 8-amide chelation- assisted C-H alkylation of 8-aminoquinolines is described. The secondary and tertiary alkyl carboxylic acids can be used as alkylating agents. This reaction allows for the highly regioselective preparation of C2-adamantyl 8-aminoquinoline scaffolds by the decarboxylative alkylation catalytic system.
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