The recent developments and applications of the traceless-Staudinger reaction in chemical biology study

Bioorthogonal reactions and their applications in selective protein manipulations, such as labeling, localization, and post-translational modification studies, are one of the most important themes in the current chemical biology frontier. Studies in recent years have demonstrated that the traceless-Staudinger reaction has been turned into a typical bioorthogonal reaction with versatile accessibility, high efficiency, and reliability. Many of its potential applications have been investigated in life science and chemical biology studies. Herein, the current developments and mechanism studies of traceless-Staudinger reaction are summarized. The typical usages in the chemical biology field will also be discussed, hoping to contribute to further modifications and developments en route.