Journal
RUSSIAN JOURNAL OF NUMERICAL ANALYSIS AND MATHEMATICAL MODELLING
Volume 29, Issue 5, Pages 265-273Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/rnam-2014-0021
Keywords
Protein sequence; information structure; protein hierarchical organization; ISAN method; informational unit
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Funding
- Presidium of the RAS
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The paper describes a new method of Information Structure Analysis (ISAN) for protein sequences. The method uses a new approximation for description of protein sequences, which allows us to detect hierarchically organized elements (Information Structure Elements (ISEL)) in them. It is shown that elements of the higher hierarchy level of information structure correspond to stable elements in the spatial structure of globular proteins. Based on the ISAN method, we propose an approach to design of the new sequences of recombinant proteins. The proposed approach was confirmed experimentally in the case of obtaining functionally active recombinant proteins.
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