Journal
RSC ADVANCES
Volume 5, Issue 98, Pages 80254-80263Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra17099k
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Funding
- NSFC (National Natural Science Foundation of China) [31300294]
- Special Fund for Agro-Scientific Research in the Public Interest [201303117]
- National Support Science and Technology Subject [2013BAI11B04]
- Fundamental Scientific Research Funds for CATAS [ITBB2015ZD02]
- Natural Science Foundation of Hainan Province [214039]
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Thirteen new sesquiterpenoids, including six guaiane type auranticanols A-F (1, 2, and 4-7) and seven carotene type auranticanols G-M (18-24) were isolated from the stems of Daphne aurantiaca Diels., along with fourteen known sesquiterpenoids (3, 8-17, 25-27) and two known tigliane diterpenoids (28, 29), and their structures were elucidated by extensively analyzing their MS and NMR spectroscopic data. A bioassay of anti-HIV activity indicated that compounds 11, 14, 19, and 28 showed definite activities with EC50 values of 2.138, 0.286, 1.773 and 0.000282 mu g mL(-1) and SI > 93.545, 93.787, 10.243, and 65 177.305, respectively.
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