Construction of nanoparticles based on amphiphilic PEI-PA polymers for bortezomib and paclitaxel co-delivery

Co-delivery is a feasible means to overcome the drawbacks of using a single drug. Herein, we report novel polymer nanoparticles based on branched polyethyleneimine and palmitic acid conjugates for bortezomib and paclitaxel co-delivery. These drug-loaded nanoparticles have a preferable particle size, high encapsulation efficiency and a pH-dependent release profile. The co-delivery system has a great advantage in suppressing tumor cell growth over single drug loaded nanoparticles, whereas the polymer nanocarrier itself shows excellent biocompatibility. The good cellular uptake properties and synergistic effects of co-delivery by polymer nanoparticles provide significant advances toward cancer therapy.