pH- and glutathione-responsive release of curcumin from mesoporous silica nanoparticles coated using tannic acid-Fe(III) complex

A novel pH-and glutathione-responsive drug delivery system has been developed by deposition of tannic acid (TA)-Fe(III) complex on the surface of mesoporous silica nanoparticles (MSN). The coating was easily accomplished within 30 seconds by successive addition of iron chloride (FeCl3) and tannic acid in aqueous dispersion of MSN (e.g. MCM-41). A hydrophobic model drug, curcumin, showed sustainable drug release under physiological condition (pH 7.4), while a rapid curcumin release was triggered by lowering the pH to 6.0 or 4.5. Moreover, curcumin release could be controlled by adjusting the glutathione level, which accelerate the decomposition of TA-Fe(III) complex by competitive liganding. Therefore, these results would allow developing novel and simple pH-and glutathione-responsive drug delivery systems with potential applications such as in biomedicine.