Synthesis, characterization, and antimicrobial activity of a novel proton salt and its Cu(II) complex

A novel proton transfer compound (H(2)Ppz)(HDipic)(2) (I) obtained from 2-(piperazin-1-yl)ethanol (Ppz) and pyridine-2,6-dicarboxylic acid (H(2)Dipic) and its Cu(II) complex (H(2)Ppz)[Cu(Dipic)(2)] center dot 6H(2)O (II) have been prepared and characterized by elemental, spectral (H-1 and C-13 NMR, IR and Uv-Vis) and thermal analyses. Magnetic measurement and single crystal X-ray diffraction methods have also been applied for compound II. The molecular structure of II consists of one 1-(2-hydroxyethyl)piperazine-1,4-diium cation, one bis(pyridinium-2,6-dicarboxylate)Cu(II) anion and six uncoordinated water molecules. In complex II, the copper ion coordinates to two oxygen and one nitrogen atoms of two pyridine-2,6-dicarboxylate molecules forming an octahedral conformation. Furthermore, the synthesised compounds (I and II) were screened for their antimicrobial activities against Gram (-) (Escherichia coli and Pseudomonas aeruginosa) and Gram (+) (Staphylococcusaureus and Bacillus cereus). The results were reported, discussed and compared with the corresponding starting materials (H(2)Dipic and Ppz).