Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 39, Issue 3, Pages 329-337Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162013020064
Keywords
triterpenoids; amides; cyanoethylation; aminopropylamino derivatives; anti-inflammatory activity
Funding
- Russian Foundation for Basic Research [11-03-12144]
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Triterpenoids with the following amine fragments in C3 and C28 positions were synthesized on the basis of betulinic and oleanolic acids: (3-aminopropoxy)-, 3-acetyl-(3-aminopropyl)amino-, 6-[bis(3-aminopropyl)amino]hexylamino-, and (3-aminopropyl)-4-aminophenylsulfonyl-4-phenylamino. Amide of betulonic acid with 4,4'-diaminodiphenylsulfonic substituent was shown to exhibit no antitumor effect, but to have a pronounced anti-inflammatory activity.
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