Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 37, Issue 2, Pages 207-216Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162010061019
Keywords
peptides; amino acid sequence; HIV-1 integrase and revertase inhibition; marine invertebrates; marine polychaetes
Funding
- MNTC [3197r]
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A homogeneous peptide with a mass of 683 Da which inhibits HIV-1 integrase with IC(50) 3 x 10(-5) M was separated from aqueous extracts of a marine worm Eunicidae sp. by multistage chromatography purification. The Asp-Leu-Hse-His-Ala-Gln structure was proposed for this peptide according to amino acid analysis, automated amino acid Edman sequences, and TLC with witness homoserine and MS/MS fragmentation. The proposed structure is the first example of a natural peptide containing an amino acid homoserine residue.
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