Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 36, Issue 5, Pages 560-573Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162010050031
Keywords
marine actinobacteria; Streptomyces sp.; Salinospora sp.; Marinophilus sp.; Micromonospora sp.; Actinomadura sp.; biologically active compounds
Funding
- Russian Foundation for Basic Research [09-04-00388]
- Presidium of the Russian Academy of Sciences
Ask authors/readers for more resources
Data on the chemical structures and biologic activities of metabolites of obligate and facultative marine actinobacteria published between 2000 and 2007 are reviewed. The structural features of five groups of metabolites related to macrolides and compounds containing lactone, quinone, and diketopiperazine residues; cyclic peptides; alkaloids; and compounds of combined nature are discussed. The review shows the large chemical diversity of metabolites of actinobacteria isolated from marine ecotopes. In addition to metabolites identical to those previously isolated from terrestrial actinobacteria, marine actinobacteria produce compounds not found in other natural sources, including microorganisms. Probably, the biosynthesis of new chemotypes of bioactive compounds by marine actinobacteria is related to the chemical adaptation of microorganisms to the marine environment. The review emphasizes the importance of chemical studies of metabolites produced by marine actinobacteria. These studies will provide new data on marine microbial producers of biologically active compounds and the chemical structures and biologic activities of new natural lowmolecular-weight bioregulators.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available