Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 35, Issue 2, Pages 254-257Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162009020150
Keywords
recombinant human insulin; polysialic acid
Funding
- Scientific and Technological Basis of Russia [2007-2-2.2-04-05-002]
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Methods of selective and nonselective covalent immobilization of genetically engineered proteins on molecules of natural polysialic acid are described by the example of human insulin. Such modification increases insulin lifetime in vivo.
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