4.6 Article

An efficient aqueous phase synthesis of benzimidazoles/benzothiazoles in the presence of β-cyclodextrin

Journal

RSC ADVANCES
Volume 5, Issue 52, Pages 41716-41720

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra16222f

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Funding

  1. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico CNPq - Brazil [Processos: 314140/2014-0, 400706/2014-8]

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Benzimidazoles/benzothiazoles were synthesized in water under neutral conditions by the reaction of aromatic aldehydes, o-phenylenediamine/2-amino thiophenol mediated by beta-cyclodextrin in high yields. beta-Cyclodextrin can be recovered and reused without significant loss of activity.

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