4.6 Article

Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles

Journal

RSC ADVANCES
Volume 5, Issue 105, Pages 86779-86783

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra17661a

Keywords

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Funding

  1. Ministerio de Ciencia e Innovacion (MICINN)
  2. Ramon y Cajal grant [RYC-2010-06082]
  3. Severo Ochoa Program (MINECO) [SEV-2013-0295]
  4. Spanish Government [MAT2012-38318-C03-02, MAT2012-35324, BIO2013-44973-R]
  5. FEDER funds
  6. China Scholarship Council [201206150053]

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We report a novel hybrid T-1/T-2 dual MRI contrast agent by the encapsulation of SPIONs (T-2 contrast agent) into an iron-based coordination polymer with T-1-weighted signal. This new hybrid material presents improved relaxometry and low cytotoxicity, which make it suitable for its use as contrast agent for MRI.

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