Journal
RUSSIAN CHEMICAL BULLETIN
Volume 59, Issue 8, Pages 1656-1659Publisher
SPRINGER
DOI: 10.1007/s11172-010-0290-1
Keywords
mangroves; endophytic fungus; metabolites; paeciloxocins; cytotoxicity
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Funding
- Administration of the National Natural Science Foundation of China [30 801 553]
- Traditional Chinese Medicine of the Guangdong Province [2 008 175, 2 008 357]
- Natural Science Foundation of the Guangdong Province [9 451 022 401 003 453]
- Guangdong Pharmaceutical University
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Paeciloxocins A and B (2-(1-hydroxy-3-methylbutyl)- and 2-(1-acetoxy-3-methylbutyl)- 11-hydroxy-9-methyl-1-methoxy-5H,7H-dibenzo[b,g]-1,5-dioxocin-5-ones), viz., two new metabolites, were isolated from the mangrove fungus Paecilomyces sp. collected from the Taiwan Strait. Their structures were elucidated by spectral methods. Paeciloxocin A exhibited strong cytotoxicity against the hepG2 cell line.
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