Polar steroidal compounds from the Far-Eastern starfish Lethasterias fusca

Nine steroidal compounds including three new steroidal glycosides, viz., sodium (24S)-3,24-di-O-(beta-D-xylopyranosyl)-5 alpha-cholestane-3 beta, 6 beta, 8,15 alpha, 24-pentol 15-sulfate (fuscaside A), (24S)-3,24-di-O-(beta-D-xylopyranosyl)-5 alpha-cholestane-3 beta, 6 beta, 8, 15 alpha, 24-pentol (fuscaside B), and (22E, 24R)-24-O-(beta-D-xylopyranosyl)-5 alpha-cholest-22-ene-3 beta, 6 alpha, 8, 15 beta, 24-pentol (desulfated minutoside A); three previously known glycosides, viz., distolasterosides D-1 and D-2 and pycno podioside A; two previously known polyhydroxysteroids, viz., 5 alpha-cholestane -3 beta, 6 alpha, 8,15 beta, 16 beta, 26-hexaol and 5 alpha-cholestan -3 beta, 4 beta, 6 alpha, 7 alpha, 8, 15 beta, 16 beta, 26-octol; and the known sodium 24,25-dihydro-marthasterone 3-sulfate were isolated from the Far-Eastern starfish Lethasterias fusca. The structures of these compounds were elucidated by NMR spectroscopy and mass spectrometry.