4.1 Article

One-step synthesis of 2-indolylalkylamines

Journal

RUSSIAN CHEMICAL BULLETIN
Volume 57, Issue 10, Pages 2220-2222

Publisher

SPRINGER
DOI: 10.1007/s11172-008-0307-1

Keywords

indole; the Fischer reaction; cyclic imines; regiochemistry; indolylalkylamines

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An efficient one-step synthesis of 2-indolylalkylamines was proposed. The synthesis involves the Fischer reaction of phenylhydrazine with cyclic imines containing a CH2 group in the alpha-position or with amino ketones containing two CH2 groups in the alpha-position with respect to the C=O group.

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