Journal
RNA
Volume 15, Issue 8, Pages 1433-1442Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.1703809
Keywords
Argonaute; GW182; miRNAs; mRNA decay; P-bodies; RBD; RRM; TNRC6A
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Funding
- Max Planck Society
- Deutsche Forschungsgemeinschaft [DFG, FOR855]
- European Commission [LSHG-CT-2006-037900]
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GW182 family proteins interact directly with Argonaute proteins and are required for miRNA-mediated gene silencing in animal cells. The domains of the GW182 proteins have recently been studied to determine their role in silencing. These studies revealed that the middle and C-terminal regions function as an autonomous domain with a repressive function that is independent of both the interaction with Argonaute proteins and of P-body localization. Such findings reinforce the idea that GW182 proteins are key components of miRNA repressor complexes in metazoa.
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