Journal
RNA BIOLOGY
Volume 11, Issue 6, Pages 669-672Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.28829
Keywords
RNA methylation; m(6)A; N-6-methyladenosine; reversible RNA modification; gene expression regulation; RNA stability; YTHDF2; RNA-binding protein; YTH domain
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Funding
- NIGMS NIH HHS [R01 GM071440, GM071440] Funding Source: Medline
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N-6-methyladenosine (m(6)A) is a prevalent modification of eukaryotic mRNAs. It regulates yeast cell fate and is essential to the development and fertility of metazoans. Although its presence in mRNA has been known since the early 1970s, the function of m(6)A remained a mystery until the spate of discoveries in the past three years. Here, we focus on the discovery of m(6)A readers (proteins that specifically recognize m(6)A), and their functions in tuning mRNA stability, as well as the broader significance of such m(6)A-dependent regulation of gene expression.
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