Journal
RNA BIOLOGY
Volume 11, Issue 5, Pages 443-456Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.28036
Keywords
small regulatory RNA; base-pairing sRNA; low GC Gram-positive bacteria; Bacillus subtilis; Streptococcus pneumoniae
Categories
Funding
- Deutsche Forschungsgemeinschaft [BR1552/7-1, 7-2, SPP1258]
- [BR1552/6-1]
- [6-3]
- [BR974/5-1]
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Small regulatory RNAs (sRNAs) that act by base-pairing were first discovered in so-called accessory DNA elements-plasmids, phages, and transposons-where they control replication, maintenance, and transposition. Since 2001, a huge body of work has been performed to predict and identify sRNAs in a multitude of bacterial genomes. The majority of chromosome-encoded sRNAs have been investigated in E. coli and other Gram-negative bacteria. However, during the past five years an increasing number of sRNAs were found in Gram-positive bacteria. Here, we outline our current knowledge on chromosome-encoded sRNAs from low-GC Gram-positive species that act by base-pairing, i. e., an antisense mechanism. We will focus on sRNAs with known targets and defined regulatory mechanisms with special emphasis on Bacillus subtilis.
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