Journal
RNA BIOLOGY
Volume 11, Issue 8, Pages 1040-1050Publisher
LANDES BIOSCIENCE
DOI: 10.4161/rna.32146
Keywords
subcellular localization; genomics; fractionation; transcriptome; RNA transport; RNA-seq; translation
Categories
Funding
- NIH HHS [DP5 OD017865] Funding Source: Medline
Ask authors/readers for more resources
The localization of mRNAs to specific subcellular sites is widespread, allowing cells to spatially restrict and regulate protein production, and playing important roles in development and cellular physiology. This process has been studied in mechanistic detail for several RNAs. However, the generality or specificity of RNA localization systems and mechanisms that impact the many thousands of localized mRNAs has been difficult to assess. In this review, we discuss the current state of the field in determining which RNAs localize, which RNA sequences mediate localization, the protein factors involved, and the biological implications of localization. For each question, we examine prominent systems and techniques that are used to study individual messages, highlight recent genome-wide studies of RNA localization, and discuss the potential for adapting other high-throughput approaches to the study of localization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available