Journal
RNA BIOLOGY
Volume 11, Issue 4, Pages 334-338Publisher
LANDES BIOSCIENCE
DOI: 10.4161/rna.28372
Keywords
microRNAs; HIV-1; post-transcriptional regulation; CD4; NFkB
Categories
Funding
- Ministry of Health
- Ricerca Finalizzata
- Ricerca Corrente
- Italian 5 x 1000 contribution
- ISS
Ask authors/readers for more resources
Several cellular microRNAs show substantial changes in expression during HIV-1 infection and their active role in the viral life cycle is progressively emerging. In the present study, we found that HIV-1 infection of Jurkat T cells significantly induces the expression of miR-222. We show that this induction depends on HIV-1 Tat protein, which is able to increase the transcriptional activity of NFkB on miR-222 promoter. Moreover, we demonstrate that miR-222 directly targets CD4, a key receptor for HIV-1, thus reducing its expression. We propose that Tat, by inducing miR-222 expression, complements the CD4 downregulation activity exerted by other viral proteins (i.e., Nef, Vpu, and Env), and we suggest that this represents a novel mechanism through which HIV-1 efficiently represses CD4 expression in infected cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available