Journal
RNA BIOLOGY
Volume 10, Issue 4, Pages 553-563Publisher
LANDES BIOSCIENCE
DOI: 10.4161/rna.24285
Keywords
tRNA; short tRNA fragment; tRF; translation repression; small RNA
Categories
Funding
- European Framework 6 SIROCCO
- Wellcome Trust Centre for Gene Regulation and Expression
- ARC [DP 130103027]
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Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived from both the 5 and 3 termini. To date, the function of these tRNA fragments (tRFs) derived from the 5 end of tRNA has not been investigated in depth. We present evidence that conserved residues in tRNA, present in all 5 tRFs, can inhibit the process of protein translation without the need for complementary target sites in the mRNA. These results implicate 5 tRFs in a new mechanism of gene regulation by small RNAs in human cells.
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