Journal
RNA BIOLOGY
Volume 9, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.18827
Keywords
MicroRNA; miR-122; Pri-miRNA; GLD-2; CAT-1; Cholesterol; Hepatitis C virus
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Funding
- BBSRC [BB/F02360X/1]
- BBSRC [BB/F02360X/1] Funding Source: UKRI
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microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication. This review will discuss the biogenesis and function of miR-122.
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