Journal
RNA BIOLOGY
Volume 9, Issue 12, Pages 1491-1497Publisher
LANDES BIOSCIENCE
DOI: 10.4161/rna.22358
Keywords
toxins; antitoxins; RNA degradation; antisense RNA; post-segregational killing; prophage
Categories
Funding
- Agence Nationale de la Recherche (subtilRNA2)
- Agence Nationale de la Recherche (asSUPYCO)
- Deutsche Forschungsgemeinschaft [BR1552/7-2, SPP1258]
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Type I toxin-antitoxin (TA) systems are widespread in bacteria and consist of a toxin-encoding mRNA and a partially overlapping antisense RNA that blocks expression of the toxin, either at the level of translation or by mRNA degradation. Four type I toxin families have so far been proposed in B. subtilis based on sequence similarity: TxpA/BsrG, BsrH/BsrE, YonT and YhzE and two (TxpA and BsrG) have been studied in some detail. Here we review what is known about these confirmed and putative toxin-antitoxin families in B. subtilis, their regulatory mechanisms, their potential roles and how they may link to the physiology of the cell.
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