Journal
RNA BIOLOGY
Volume 8, Issue 1, Pages 71-76Publisher
LANDES BIOSCIENCE
DOI: 10.4161/rna.8.1.14299
Keywords
microRNA; miRNA; TGF beta; BMP; smads; biogenesis; drosha; processing
Categories
Funding
- NHLBI NIH HHS [R01HL082854, R01 HL093154, R01HL093154, T32 HL069770, R01 HL082854, R01 HL108317, T32HL069770] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL069770, R01HL093154, R01HL108317, R01HL082854] Funding Source: NIH RePORTER
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microRNAs (miRNAs) are short, 21-24 nucleotide (nt), non-coding RNAs that post-transcriptionally regulate the expression of messenger RNAs (mRNAs). Through the regulation of their cognate mRNAs, miRNAs control diverse aspects of biology, including development, cellular differentiation, proliferation, metabolism and death. Thus, miRNAs play a critical role in the determination of normal cellular physiology and misexpression of miRNAs leads to pathological responses. Understanding the mechanisms that control miRNA expression is an important step forward as novel functions of miRNAs continue to be uncovered. In addition to transcriptional regulation, multiple pathways of post-transcriptional modulation of miRNA expression have been uncovered. In this review we discuss the role of the Smads in the regulation of miRNA processing in response to Transforming Growth Factor beta stimulation.
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