Journal
RNA BIOLOGY
Volume 7, Issue 3, Pages 300-304Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.7.3.11837
Keywords
miR-205; breast cancer; mammary gland development; stem cells
Categories
Funding
- Department of Defense Breast Cancer Program [DAMD W81XWH-06-1-0716]
- Komen Post-doctoral fellowship [PDF0707744]
- NIH [CA-16303]
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Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of its regulation and targets. Additionally, miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. The role that miR-205 plays in tumor formation and metastasis is likely context-dependent as reports have indicated that it may function as either a tumor suppressor or an oncogene. The role that miR-205 plays in directing stem cell fate is still unknown.
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