Journal
RNA BIOLOGY
Volume 6, Issue 2, Pages 175-178Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.6.2.8196
Keywords
FMRP; FXR1P; microRNA; translation regulation; phosphorylation; mRNA
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Funding
- NICHD NIH HHS [R01 HD041591, HD41591] Funding Source: Medline
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Small, genomically-encoded microRNAs are important factors in the regulation of mRNA translation. Although their biogenesis is relatively well-defined, it is still unclear how they are recruited to their mRNA targets. The fragile X mental retardation protein family members, FMRP, FXR1P and FYR2P are RNA binding proteins that regulate translation of their cargo mRNAs. All three proteins, in addition to the single Drosophila ortholog, dFmrp, associate physically and functionally with the microRNA pathway. In this review, we summarize what is known about the role of the fragile X family members in translation regulation, highlighting evidence for their association with the microRNA pathway. In addition, we present a new model for the effect of phosphorylation on FMRP function, where phosphorylation of FMRP inhibits Dicer binding, leading to the accumulation of precursor microRNAs and possibly a paucity of activating microRNAs.
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