Journal
RNA BIOLOGY
Volume 6, Issue 1, Pages 17-20Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.6.1.7440
Keywords
DExD/H-box protein; RNA helicase; splicing; nuclear export; translation; post-transcriptional gene regulation
Categories
Ask authors/readers for more resources
DExD/H-box RNA helicases are involved in almost all steps of the eukaryotic mRNA biogenesis. The DEAD-box protein Ded1p/DDX3 is conserved from yeast to human. Various lines of genetic and biochemical evidence have indicated a role of the yeast Ded1p in translation and, most likely, in precursor mRNA splicing as well. In contrast, although recent studies have begun to reveal the function of the mammalian DDX3 in translation control, its exact role remains vague and even controversial. Here, we review these findings and particularly discuss the functional aspects of Ded1p/DDX3 in translation control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available