Journal
RNA BIOLOGY
Volume 6, Issue 1, Pages 49-53Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.6.1.7574
Keywords
microRNA; miRNA; pri-miRNA; transcription; promoter; Pol II
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Funding
- NIA NIH HHS [R01 AG033921] Funding Source: Medline
- NIGMS NIH HHS [GM64701, R01 GM064701] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM064701] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG033921] Funding Source: NIH RePORTER
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Transcriptional regulation of microRNA (miRNA) expression is one of the least understood aspects of miRNA biogenesis. In C elegans the list of miRNAs whose transcriptional control has been described in some detail is currently limited to four: let-7, lin-4, lsy-6, and mir-61. Each of these genes has been shown experimentally to be transcriptionaly regulated by cis- and/or trans-acting factors that either promote or inhibit expression. Additionally, computational methods based on conservation among miRNA genes have yielded predicted regulatory sequences in C elegans that may function to regulate miRNA expression on a genome-wide scale.
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