Journal
RNA BIOLOGY
Volume 5, Issue 3, Pages 115-119Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.5.3.6558
Keywords
microRNA; E-cadherin; ZEB; epithelial-mesenchymal transition; metastasis
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Funding
- NCI NIH HHS [R01 CA141062] Funding Source: Medline
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MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting.
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