Journal
RHEUMATOLOGY INTERNATIONAL
Volume 32, Issue 5, Pages 1245-1249Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-010-1755-0
Keywords
SLEDAI; End-stage renal disease; Rituximab; Membranous glomerulonephritis; B-cells
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Eight patients with refractory lupus nephritis received rituximab after failing standard sequential therapy and were followed for 104 weeks after the infusion. One patient died secondary to a complicated pregnancy but had stable renal function. Three patients received a re-infusion of rituximab approximately 12 months apart due to a renal flare; during the second year of follow-up, those patients progressed toward ESRD. The four remaining patients demonstrated improvements in SLEDAI score, CrCl, and proteinuria with maintenance of their standard immunosuppressive therapy and did not require a re-infusion of rituximab. Although rituximab as induction therapy for refractory lupus nephritis has been shown to have a good response, its efficacy in long-term assessments demonstrates disappointing results.
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