Journal
RHEUMATOLOGY INTERNATIONAL
Volume 31, Issue 6, Pages 841-842Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-010-1485-3
Keywords
Systemic sclerosis; Scleroderma; Rituximab; Interstitial lung disease; B cells; Fibrosis; Skin thickening; Rheumatic diseases
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Several lines of evidence from basic research indicate that B cells may contribute to the pathogenesis of systemic sclerosis. Clinical studies as well have provided preliminary data pointing to the direction that B-cell depletion with rituximab might be a therapeutic option for patients with this debilitating disease.
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