Journal
RHEUMATOLOGY INTERNATIONAL
Volume 30, Issue 9, Pages 1249-1252Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-010-1400-y
Keywords
Asp299Gly and Thr399Ile polymorphisms; Toll-like receptor 4; Rheumatoid arthritis; Chinese Han people in Yunnan Province
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Funding
- National Nature Science Foundation of China [30660175]
- Yunnan Province Young Scientist Project [2009CI044]
- Ministry of Education of China [81067301]
- National Found for Fostering Talents of Basic Science [J0730652]
- Yunnan University Experiment Teaching Center of Life Sciences
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Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of synovium and subsequent joint destruction. Recently, genetic polymorphisms within the toll-like receptor 4 (TLR4) genes have been reported to be associated with RA. To analyze the association between the genetic polymorphisms within TLR4 gene and the susceptibility to RA in Chinese people, two functional variants, Asp299Gly and Thr399Ile, in the TLR4 gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing techniques from 213 RA patients and 247 ethnically matched controls. None polymorphisms of Asp299Gly and Thr399Ile were detected in all RA cases and controls, which indicates that there is no relevance between these two SNPs and RA in the Chinese Han population. Further studies with extended single nucleotide polymorphisms (SNP) should be performed.
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