Journal
RHEUMATOLOGY INTERNATIONAL
Volume 31, Issue 4, Pages 529-532Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-009-1222-y
Keywords
Antisynthetase syndrome; Anti-Jo-1 antibody; Rheumatoid arthritis
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Funding
- Korean government (MOEHRD) [KRF-2008-331-E00143]
- Chonnam National University Hospital Research Institute of Clinical Medicine [CRI09025-1]
- Center for Biomedical Human Resources at Chonnam National University
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Rheumatoid arthritis (RA) and antisynthetase syndrome (ASS) are distinct clinical syndromes, and their co-occurrence is rarely encountered. The authors report the case of a 56-year-old female patient with RA of 3 years duration who suddenly developed ASS, and include a review of the literature. The patient was diagnosed with ASS based on; positivity for anti-histidyl-tRNA synthetase (Jo-1) antibody, interstitial lung disease, polyarthritis, and mechanic's hands. High-dose corticosteroid and pulse intravenous cyclophosphamide were used to control the ASS. This case demonstrates that ASS should be considered during clinical presentations due to its potential overlap with RA.
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